Analysis of the therapeutic potential of epigenetic «Reader» proteins in rheumatoid arthritis

Dr. Kerstin Klein, Center of Experimental Rheumatology, Department of Rheumatology, University Hospital of Zurich

In our project, we are examining the therapeutic potential of epigenetic enzymes, in particular of so-called «reader» proteins in rheumatoid arthritis. "Reader" proteins and central regulators which determine, which genes will be activated at what time. Die inhibition of epigenetic enzymes is a promising approach future approach towards new therapies for rheumatoid arthritis and other inflammatory diseases. Studies to identify target genes and possible undesirable side effects are therefore essential to assess their therapeutic potential.