Improved therapeutics and prevention

Research only benefits patients if it can be brought from the laboratory to them. Translational research aims to "translate" findings in basic research into medical application. Clinical research goes a step further and works directly with patients. Some projects use the knowledge and expertise acquired through the basic research to develop new drugs or therapies. Others combine research and evaluation with the participation of patients or people judged to be at risk from disease.

Funding projects:

• Discovering new biomarkers to identify individuals in pre-clinical stages of rheumatoid arthritis

• Why does rheumatoid arthritis start in specific joints?

Ongoing projects:

• Steering drug discovery in arthritis: Single cell analysis of joint tissue biopsies in drug resistant rheumatoid arthritis

Past projects:

• Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions.

• Prevotella copri in individuals at risk for rheumatoid arthritis

• Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still's disease