Specific contributions and regulation of inflammasomes
Specific contributions and regulation of inflammasomes in systemic-onset juvenile idiopathic arthritis: from bench to bedside
Prof. Fabio Martinon, Lausanne University and Center of Infection and Immunity, Department of Biochemistry, University of Lausanne
Systemic-onset juvenile idiopathic arthritis (SoJIA) is a serious form of childhood arthritis, which is painful and causes great suffering due to arthritis in joints accompanied by fever, tiredness, rash, loss of weight and appetite.
This research investigates the role and the regulation of innate immune system receptors and sensors, called inflammasomes, which induce inflammation in response to cellular infection or stress. Inflammasomes may be implicated in systemic auto-inflammatory diseases, such as systemic-onset juvenile idiopathic arthritis (SoJIA).
Our study aims to provide answers to key biological and medical questions regarding the specific role of inflammasomes in how SoJIA develops. The understanding of inflammasomes role and regulation in the outbreak of SoJIA may provide specific biomarkers for early diagnosis and treatment of the disease.
Download the project summary.